Nizam College has Central Instrumentation Facility and Research Advisory Committee to support the research activities among the staff and students. The Faculty receives grants from various funding agencies like UGC (Major and Minor research Projects, Start-Up Grants, SERO), ICSSR, DST (FIST, SERB) CPE. The institution has developed linkages and collaborations with various state, national and international institutions like National Dwang Ho University, Taiwan,Planetary Society of India, Physitech; Planetary Society of India; Pingle Govt. College for Women, Waddepally, Warangal; S.R. Government Arts and science College, Kotthagudem; Government Degree College, Hussaini Aalam; National Environmental Engineering Research Institute, Replica Miniatures.

The institution has tie up with the Central Facilities for Research Development (CFRD), Osmania University. The teachers and students visit National level science and research institutions like CCMB, IICT, NIN, ICRISAT etc. The College provides all support for research and development like sanctioning duty leaves, encouraging faculty to interact with faculty from other institutions.

The College faculty has 177 research publications (peer reviewed), 12 Patents and 36 research projects in last five years.

The College participates and organizes various extension activities through its NSS and NCC units, Biodiversity Club and through OYSTER. These activities are a platform for not only understanding social issues and challenges, but also imbibing social responsibilities, involving community towards community development. Activities like blood donation camps; awareness programmes on suicide prevention, AIDS awareness, RTI; gender sensitisation programmes; swach Bharat programmes are great sources of learning and contributing towards the community.